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Connecting the diagnosis of male infertility to the window into future health trajectories


SINGAPORE, May 1, 2022 /PRNewswire/ — Male factor infertility emerges as likely biomarkers of later health events, including hospital treatment and possible premature death from conditions such as cancer, cardiovascular and metabolic disease.

(PRNewsfoto/Asia-Pacific Initiative on Reproduction)

Lifestyle and social factors, including partner-child relationships, may also be closely linked to fertility status and men’s future health trajectories.

Speaking at the 2022 Congress of the Asia-Pacific Initiative on Reproductive (ASPIRE), Male Reproductive Health Specialist, Professor Michael Eisenberg said a series of studies had shown that men living with infertility were generally in poorer health throughout life than fertile men.

Professor Eisenberg, Director of Male Reproductive Medicine and Surgery at Stanford University in United Statessaid today that conditions such as hypertension, cancer, endocrine and heart disease have been linked to impaired sperm quality identified when male infertility is diagnosed in men.

“In countries like United States infertility affects up to one in seven couples, and in nearly 50% of cases, a male factor, such as low sperm count or poor sperm motility, explains reproductive difficulties,” he said. Explain.

“But there is now increasing evidence that aberrations in male reproductive capacity may be a harbinger of other medical conditions later in life compared to fertile males.”

The ASPIRE Congress in virtual format connects scientists, clinicians, nurses and counselors from more than 100 countries to address the barriers faced by couples seeking parenthood and the latest advances in infertility treatment.

Professor Eisenberg said some of the best data on male infertility and future health has emerged from Denmark where up to 10 percent of all births result from assisted reproductive technology, such as IVF.

“Danish research has demonstrated that sperm quality is a marker of subsequent hospital treatment for other health factors,” he explained. “It showed that men with low sperm count put them on a trajectory of poor health, independent of other factors such as obesity or smoking.

“In United States research linking health insurance claims for fertility diagnosis and subsequent health interventions has demonstrated an association with male infertility and higher risk of ischemic heart and vascular disease and diabetes.

“The etiology of the association between male infertility and future health is uncertain, but there have been suggestions of genetic, hormonal, developmental, social and other health-related factors that may have lifelong impacts. of life on men’s reproductive and overall health.”

Professor Eisenberg also presented data at the ASPIRE Congress exploring the relationship factors between partner and child and mortality.

For example, men living with their partners and children with single custodial fathers had significantly lower mortality rates than cohabiting childless men and single childless men. This suggests an association between children and future health factors.

Professor Eisenberg said studies to date have involved men with no underlying health conditions at the time of infertility diagnosis and other factors such as socio-economic status have been weighted in the research.

He pointed to the need for new studies that track the health trajectories of men diagnosed with infertility and whether or not genetic or hormonal factors may also be involved.

“Reproductive specialists have an important role to play in counseling men diagnosed with fertility problems to educate them about future health risks that could be avoided through lifestyle changes, including diet and exercise,” he added. “This in turn could have positive impacts on a man’s reproductive health.”

For more information on the ASPIRE Congress 2022, visit www.aspire-2022.com

SOURCE Asia-Pacific Initiative on Reproduction